Vitamin C induces specific demethylation of H3K9me2 in mouse embryonic stem cells via Kdm3a/b

Vitamin C induces specific demethylation of H3K9me2 in mouse embryonic stem cells via Kdm3a/b

Abstract Background Histone methylation patterns regulate gene expression and are highly dynamic during development. The erasure of histone methylation is carried out by histone demethylase enzymes. We had previously shown that vitamin C enhances the activity of Tet enzymes in embryonic stem (ES) ce...

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Bibliographic Details
Main Authors: Kevin T. Ebata, Kathryn Mesh, Shichong Liu, Misha Bilenky, Alexander Fekete, Michael G. Acker, Martin Hirst, Benjamin A. Garcia, Miguel Ramalho-Santos
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Epigenetics & Chromatin
Subjects:
Vitamin C
Histone methylation
Histone lysine demethylase
Epigenetics
Embryonic stem cells
Online Access:http://link.springer.com/article/10.1186/s13072-017-0143-3

Internet

http://link.springer.com/article/10.1186/s13072-017-0143-3

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