Translational control of ERK signaling through miRNA/4EHP-directed silencing

Translational control of ERK signaling through miRNA/4EHP-directed silencing

MicroRNAs (miRNAs) exert a broad influence over gene expression by directing effector activities that impinge on translation and stability of mRNAs. We recently discovered that the cap-binding protein 4EHP is a key component of the mammalian miRNA-Induced Silencing Complex (miRISC), which mediates g...

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Bibliographic Details
Main Authors: Seyed Mehdi Jafarnejad, Clément Chapat, Edna Matta-Camacho, Idit Anna Gelbart, Geoffrey G Hesketh, Meztli Arguello, Aitor Garzia, Sung-Hoon Kim, Jan Attig, Maayan Shapiro, Masahiro Morita, Arkady Khoutorsky, Tommy Alain, Christos, G Gkogkas, Noam Stern-Ginossar, Thomas Tuschl, Anne-Claude Gingras, Thomas F Duchaine, Nahum Sonenberg
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-02-01
Series:eLife
Subjects:
4EHP
miRNA
mRNA Translation
CCR4-NOT
DUSP6
ERK
Online Access:https://elifesciences.org/articles/35034

Internet

https://elifesciences.org/articles/35034

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