Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin

Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin

Gliotoxin (GT), produced by the pulmonary pathogen A. fumigatus, induces detachment-induced apoptosis (anoikis) of lung epithelial cells and likely promotes invasion. Here, the authors show that GT covalently modifies integrins at the RGD binding site followed by activation of RhoA-ROCK-MKK4/7-JNK s...

Full description

Bibliographic Details
Main Authors: Florian Haun, Simon Neumann, Lukas Peintner, Katrin Wieland, Jüri Habicht, Carsten Schwan, Kristine Østevold, Maria Magdalena Koczorowska, Martin Biniossek, Matthias Kist, Hauke Busch, Melanie Boerries, Roger J. Davis, Ulrich Maurer, Oliver Schilling, Klaus Aktories, Christoph Borner
Format: Article
Language:English
Published: Nature Publishing Group 2018-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05850-w

Internet

https://doi.org/10.1038/s41467-018-05850-w

Similar Items