Inhibition of histone deacetylase 3 causes replication stress in cutaneous T cell lymphoma.

Inhibition of histone deacetylase 3 causes replication stress in cutaneous T cell lymphoma.

Given the fundamental roles of histone deacetylases (HDACs) in the regulation of DNA repair, replication, transcription and chromatin structure, it is fitting that therapies targeting HDAC activities are now being explored as anti-cancer agents. In fact, two histone deacetylase inhibitors (HDIs), SA...

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Bibliographic Details
Main Authors: Christina E Wells, Srividya Bhaskara, Kristy R Stengel, Yue Zhao, Bianca Sirbu, Benjamin Chagot, David Cortez, Dineo Khabele, Walter J Chazin, Andrew Cooper, Vincent Jacques, James Rusche, Christine M Eischen, Laura Y McGirt, Scott W Hiebert
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3718806?pdf=render

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http://europepmc.org/articles/PMC3718806?pdf=render

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