Crystal Structure of Botulinum Neurotoxin A2 in Complex with the Human Protein Receptor SV2C Reveals Plasticity in Receptor Binding

Crystal Structure of Botulinum Neurotoxin A2 in Complex with the Human Protein Receptor SV2C Reveals Plasticity in Receptor Binding

Botulinum neurotoxins (BoNTs) are a family of highly dangerous bacterial toxins, with seven major serotypes (BoNT/A-G). Members of BoNTs, BoNT/A1 and BoNT/B1, have been utilized to treat an increasing number of medical conditions. The clinical trials are ongoing for BoNT/A2, another subtype of BoNT/...

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Bibliographic Details
Main Authors: Robert Gustafsson, Sicai Zhang, Geoffrey Masuyer, Min Dong, Pål Stenmark
Format: Article
Language:English
Published: MDPI AG 2018-04-01
Series:Toxins
Subjects:
botulinum toxin
cell surface receptor
N-linked glycosylation
neurotoxin
protein structure
protein–protein interaction
extracellular domain
membrane protein
structural biology
X-ray crystallography
Online Access:http://www.mdpi.com/2072-6651/10/4/153

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http://www.mdpi.com/2072-6651/10/4/153

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