Methylome analyses of three glioblastoma cohorts reveal chemotherapy sensitivity markers within DDR genes

Methylome analyses of three glioblastoma cohorts reveal chemotherapy sensitivity markers within DDR genes

Abstract Background Gliomas evade current therapies through primary and acquired resistance and the effect of temozolomide is mainly restricted to methylguanin‐O6-methyltransferase promoter (MGMT) promoter hypermethylated tumors. Further resistance markers are largely unknown and would help for bett...

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Bibliographic Details
Main Authors: Tobias Kessler, Anne Berberich, Ahmed Sadik, Felix Sahm, Thierry Gorlia, Christoph Meisner, Dirk C. Hoffmann, Antje Wick, Philipp Kickingereder, Petra Rübmann, Martin Bendszus, Christiane Opitz, Michael Weller, Martin van denBent, Roger Stupp, Frank Winkler, Alba Brandes, Andreas vonDeimling, Michael Platten, Wolfgang Wick
Format: Article
Language:English
Published: Wiley 2020-11-01
Series:Cancer Medicine
Online Access:https://doi.org/10.1002/cam4.3447

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https://doi.org/10.1002/cam4.3447

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