Development of Relaxin-3 Agonists and Antagonists Based on Grafted Disulfide-Stabilized Scaffolds

Development of Relaxin-3 Agonists and Antagonists Based on Grafted Disulfide-Stabilized Scaffolds

Relaxin-3 is a neuropeptide with important roles in metabolism, arousal, learning and memory. Its cognate receptor is the relaxin family peptide-3 (RXFP3) receptor. Relaxin-3 agonist and antagonist analogs have been shown to be able to modulate food intake in rodent models. The relaxin-3 B-chain is...

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Bibliographic Details
Main Authors: Han Siean Lee, Michael Postan, Angela Song, Richard J. Clark, Ross A. D. Bathgate, Linda M. Haugaard-Kedström, K. Johan Rosengren
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Chemistry
Subjects:
relaxin-3
RXFP3
grafting
apamin
VhTI
disulfide-scaffold
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2020.00087/full

Internet

https://www.frontiersin.org/article/10.3389/fchem.2020.00087/full

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