Structure of the CLC-1 chloride channel from Homo sapiens

CLC channels mediate passive Cl− conduction, while CLC transporters mediate active Cl− transport coupled to H+ transport in the opposite direction. The distinction between CLC-0/1/2 channels and CLC transporters seems undetectable by amino acid sequence. To understand why they are different function...

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Bibliographic Details
Main Authors: Eunyong Park, Roderick MacKinnon
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-05-01
Series:eLife
Subjects:
CLC
Online Access:https://elifesciences.org/articles/36629