Systematic genetic analysis of the MHC region reveals mechanistic underpinnings of HLA type associations with disease

Systematic genetic analysis of the MHC region reveals mechanistic underpinnings of HLA type associations with disease

The MHC region is highly associated with autoimmune and infectious diseases. Here we conduct an in-depth interrogation of associations between genetic variation, gene expression and disease. We create a comprehensive map of regulatory variation in the MHC region using WGS from 419 individuals to cal...

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Bibliographic Details
Main Authors: Matteo D'Antonio, Joaquin Reyna, David Jakubosky, Margaret KR Donovan, Marc-Jan Bonder, Hiroko Matsui, Oliver Stegle, Naoki Nariai, Agnieszka D'Antonio-Chronowska, Kelly A Frazer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-11-01
Series:eLife
Subjects:
major histocompatibility complex
eQTLs
gene expression
HLA types
Online Access:https://elifesciences.org/articles/48476

Internet

https://elifesciences.org/articles/48476

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