Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression

Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression

Despite being structurally similar, the insulin receptor (IR) and insulin growth factor I receptor (IGF1R) elicit distinct signalling pathways. Here the authors use receptor chimeras to unveil that IR and IGF1R signalling is related primarily to differences in their intracellular juxtamembrane regio...

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Bibliographic Details
Main Authors: Weikang Cai, Masaji Sakaguchi, Andre Kleinridders, Gonzalo Gonzalez-Del Pino, Jonathan M. Dreyfuss, Brian T. O’Neill, Alfred K. Ramirez, Hui Pan, Jonathon N. Winnay, Jeremie Boucher, Michael J. Eck, C. Ronald Kahn
Format: Article
Language:English
Published: Nature Publishing Group 2017-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms14892

Internet

https://doi.org/10.1038/ncomms14892

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