High cerebrospinal amyloid-β 42 is associated with normal cognition in individuals with brain amyloidosis

High cerebrospinal amyloid-β 42 is associated with normal cognition in individuals with brain amyloidosis

Background: Brain amyloidosis does not invariably predict dementia. We hypothesized that high soluble 42-amino acid β amyloid (Aβ42) peptide levels are associated with normal cognition and hippocampal volume despite increasing brain amyloidosis. Methods: This cross-sectional study of 598 amyloid-pos...

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Bibliographic Details
Main Authors: Andrea Sturchio, Alok K. Dwivedi, Christina B. Young, Tarja Malm, Luca Marsili, Jennifer S. Sharma, Abhimanyu Mahajan, Emily J. Hill, Samir EL Andaloussi, Kathleen L. Poston, Fredric P. Manfredsson, Lon S. Schneider, Kariem Ezzat, Alberto J. Espay
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:EClinicalMedicine
Subjects:
Β-amyloid
Alzheimer's disease
Hippocampus
Atrophy
Online Access:http://www.sciencedirect.com/science/article/pii/S2589537021002686

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http://www.sciencedirect.com/science/article/pii/S2589537021002686

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