Germline nuclear-predominant Pten murine model exhibits impaired social and perseverative behavior, microglial activation, and increased oxytocinergic activity

Germline nuclear-predominant Pten murine model exhibits impaired social and perseverative behavior, microglial activation, and increased oxytocinergic activity

Abstract Background Autism spectrum disorder (ASD) has a strong genetic etiology. Germline mutation in the tumor suppressor gene PTEN is one of the best described monogenic risk cases for ASD. Animal modeling of cell-specific Pten loss or mutation has provided insight into how disruptions to the fun...

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Bibliographic Details
Main Authors: Nick Sarn, Stetson Thacker, Hyunpil Lee, Charis Eng
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Molecular Autism
Subjects:
PTEN mutation
Autism spectrum disorder
Mouse model
Social impairment
Microglia
Complement
Online Access:https://doi.org/10.1186/s13229-021-00448-4

Internet

https://doi.org/10.1186/s13229-021-00448-4

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