High-resolution transcriptional and morphogenetic profiling of cells from micropatterned human ESC gastruloid cultures

High-resolution transcriptional and morphogenetic profiling of cells from micropatterned human ESC gastruloid cultures

During mammalian gastrulation, germ layers arise and are shaped into the body plan while extraembryonic layers sustain the embryo. Human embryonic stem cells, cultured with BMP4 on extracellular matrix micro-discs, reproducibly differentiate into gastruloids, expressing markers of germ layers and ex...

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Bibliographic Details
Main Authors: Kyaw Thu Minn, Yuheng C Fu, Shenghua He, Sabine Dietmann, Steven C George, Mark A Anastasio, Samantha A Morris, Lilianna Solnica-Krezel
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-11-01
Series:eLife
Subjects:
gastrulation
germ layers
cell sorting
primordial germ cells
amnion
trophectoderm
Online Access:https://elifesciences.org/articles/59445

Internet

https://elifesciences.org/articles/59445

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