CFTR Rescue in Intestinal Organoids with GLPG/ABBV-2737, ABBV/GLPG-2222 and ABBV/GLPG-2451 Triple Therapy

CFTR Rescue in Intestinal Organoids with GLPG/ABBV-2737, ABBV/GLPG-2222 and ABBV/GLPG-2451 Triple Therapy

Cystic fibrosis transmembrane conductance regulator (CFTR) modulators have transformed the treatment of cystic fibrosis (CF) by targeting the basis of the disease. In particular, treatment regimen consisting of multiple compounds with complementary mechanisms of action have been shown to result in o...

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Bibliographic Details
Main Authors: Eyleen de Poel, Sacha Spelier, Ricardo Korporaal, Ka Wai Lai, Sylvia F. Boj, Katja Conrath, Cornelis K. van der Ent, Jeffrey M. Beekman
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Molecular Biosciences
Subjects:
cystic fibrosis
CFTR
F508del
forskolin induced swelling assay
intestinal organoids
personalized medicine
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.698358/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2021.698358/full

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