Antigen presenting cell-mediated expansion of human umbilical cord blood yields log-scale expansion of natural killer cells with anti-myeloma activity.

Antigen presenting cell-mediated expansion of human umbilical cord blood yields log-scale expansion of natural killer cells with anti-myeloma activity.

Natural killer (NK) cells are important mediators of anti-tumor immunity and are active against several hematologic malignancies, including multiple myeloma (MM). Umbilical cord blood (CB) is a promising source of allogeneic NK cells but large scale ex vivo expansion is required for generation of cl...

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Bibliographic Details
Main Authors: Nina Shah, Beatriz Martin-Antonio, Hong Yang, Stephanie Ku, Dean A Lee, Laurence J N Cooper, William K Decker, Sufang Li, Simon N Robinson, Takuya Sekine, Simrit Parmar, John Gribben, Michael Wang, Katy Rezvani, Eric Yvon, Amer Najjar, Jared Burks, Indreshpal Kaur, Richard E Champlin, Catherine M Bollard, Elizabeth J Shpall
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3800010?pdf=render

Internet

http://europepmc.org/articles/PMC3800010?pdf=render

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