Inherent dynamics of the acid-sensing ion channel 1 correlates with the gating mechanism.
The acid-sensing ion channel 1 (ASIC1) is a key receptor for extracellular protons. Although numerous structural and functional studies have been performed on this channel, the structural dynamics underlying the gating mechanism remains unknown. We used normal mode analysis, mutagenesis, and electro...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2009-07-01
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| Series: | PLoS Biology |
| Online Access: | http://europepmc.org/articles/PMC2701601?pdf=render |