LRRK2 Biology from structure to dysfunction: research progresses, but the themes remain the same

Abstract Since the discovery of leucine-rich repeat kinase 2 (LRRK2) as a protein that is likely central to the aetiology of Parkinson’s disease, a considerable amount of work has gone into uncovering its basic cellular function. This effort has led to the implication of LRRK2 in a bewildering range...

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Bibliographic Details
Main Authors: Daniel C. Berwick, George R. Heaton, Sonia Azeggagh, Kirsten Harvey
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Molecular Neurodegeneration
Subjects:
Online Access:https://doi.org/10.1186/s13024-019-0344-2