Levels of mutant huntingtin influence the phenotypic severity of Huntington disease in YAC128 mouse models

Levels of mutant huntingtin influence the phenotypic severity of Huntington disease in YAC128 mouse models

Huntington disease (HD) is a devastating neuropsychiatric disease caused by expansion of a trinucleotide repeat (CAG) in the HD gene. Neuropathological changes include the appearance of N-terminal huntingtin fragments, decreased brain weight and apoptotic neuronal loss in a select subset of neurons...

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Bibliographic Details
Main Authors: Rona K. Graham, Elizabeth J. Slow, Yu Deng, Nagat Bissada, Ge Lu, Jacqueline Pearson, Jacqueline Shehadeh, Blair R. Leavitt, Lynn A. Raymond, Michael R. Hayden
Format: Article
Language:English
Published: Elsevier 2006-02-01
Series:Neurobiology of Disease
Subjects:
Huntington disease
Neurodegeneration
Mutant huntingtin
Behavior
Neuropathology
Excitotoxicity
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105002317

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http://www.sciencedirect.com/science/article/pii/S0969996105002317

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