Disruption of Rab11 activity in a knock-in mouse model of Huntington's disease

Disruption of Rab11 activity in a knock-in mouse model of Huntington's disease

The Huntington's disease (HD) mutation causes polyglutamine expansion in huntingtin (Htt) and neurodegeneration. Htt interacts with a complex containing Rab11GDP and is involved in activation of Rab11, which functions in endosomal recycling and neurite growth and long-term potentiation. Like ot...

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Bibliographic Details
Main Authors: Xueyi Li, Ellen Sapp, Kathryn Chase, Laryssa A. Comer-Tierney, Nicholas Masso, Jonathan Alexander, Patrick Reeves, Kimberly B. Kegel, Antonio Valencia, Miguel Esteves, Neil Aronin, Marian DiFiglia
Format: Article
Language:English
Published: Elsevier 2009-11-01
Series:Neurobiology of Disease
Subjects:
Huntingtin
Knock-in mouse
Rab11
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109002216

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http://www.sciencedirect.com/science/article/pii/S0969996109002216

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