Modulation of Keap1/Nrf2/ARE Signaling Pathway by Curcuma- and Garlic-Derived Hybrids

Modulation of Keap1/Nrf2/ARE Signaling Pathway by Curcuma- and Garlic-Derived Hybrids

Nrf2 is a basic leucine zipper transcription factor that binds to the promoter region of the antioxidant response element (ARE), inducing the coordinated up-regulation of antioxidant and detoxification genes. We recently synthesized a set of new molecules by combining the functional moieties of curc...

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Bibliographic Details
Main Authors: Melania Maria Serafini, Michele Catanzaro, Francesca Fagiani, Elena Simoni, Roberta Caporaso, Marco Dacrema, Irene Romanoni, Stefano Govoni, Marco Racchi, Maria Daglia, Michela Rosini, Cristina Lanni
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Pharmacology
Subjects:
curcumin
Nrf2
Keap1
NQO1
HO-1
dimethyl fumarate
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01597/full

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https://www.frontiersin.org/article/10.3389/fphar.2019.01597/full

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