Systematic in vivo analysis of the intrinsic determinants of amyloid Beta pathogenicity.
Protein aggregation into amyloid fibrils and protofibrillar aggregates is associated with a number of the most common neurodegenerative diseases. We have established, using a computational approach, that knowledge of the primary sequences of proteins is sufficient to predict their in vitro aggregati...
Main Authors: | Leila M Luheshi, Gian Gaetano Tartaglia, Ann-Christin Brorsson, Amol P Pawar, Ian E Watson, Fabrizio Chiti, Michele Vendruscolo, David A Lomas, Christopher M Dobson, Damian C Crowther |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2007-10-01
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Series: | PLoS Biology |
Online Access: | https://doi.org/10.1371/journal.pbio.0050290 |
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