Checkpoint Blockade Reverses Anergy in IL-13Rα2 Humanized scFv-Based CAR T Cells to Treat Murine and Canine Gliomas

Checkpoint Blockade Reverses Anergy in IL-13Rα2 Humanized scFv-Based CAR T Cells to Treat Murine and Canine Gliomas

We generated two humanized interleukin-13 receptor α2 (IL-13Rα2) chimeric antigen receptors (CARs), Hu07BBz and Hu08BBz, that recognized human IL-13Rα2, but not IL-13Rα1. Hu08BBz also recognized canine IL-13Rα2. Both of these CAR T cell constructs demonstrated superior tumor inhibitory effects in a...

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Bibliographic Details
Main Authors: Yibo Yin, Alina C. Boesteanu, Zev A. Binder, Chong Xu, Reiss A. Reid, Jesse L. Rodriguez, Danielle R. Cook, Radhika Thokala, Kristin Blouch, Bevin McGettigan-Croce, Logan Zhang, Christoph Konradt, Alexandria P. Cogdill, M. Kazim Panjwani, Shuguang Jiang, Denis Migliorini, Nadia Dahmane, Avery D. Posey, Jr., Carl H. June, Nicola J. Mason, Zhiguo Lin, Donald M. O’Rourke, Laura A. Johnson
Format: Article
Language:English
Published: Elsevier 2018-12-01
Series:Molecular Therapy: Oncolytics
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770518300202

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http://www.sciencedirect.com/science/article/pii/S2372770518300202

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