Extracellular Citrate Fuels Cancer Cell Metabolism and Growth

Extracellular Citrate Fuels Cancer Cell Metabolism and Growth

Cancer cells need excess energy and essential nutrients/metabolites not only to divide and proliferate but also to migrate and invade distant organs for metastasis. Fatty acid and cholesterol synthesis, considered a hallmark of cancer for anabolism and membrane biogenesis, requires citrate. We revie...

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Bibliographic Details
Main Authors: Sebastian Haferkamp, Konstantin Drexler, Marianne Federlin, Hans J. Schlitt, Mark Berneburg, Jerzy Adamski, Andreas Gaumann, Edward K. Geissler, Vadivel Ganapathy, E. Kenneth Parkinson, Maria E. Mycielska
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
cancer
metabolism
transporter
cancer associated fibroblast (CAF)
senescent fibroblasts
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.602476/full

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https://www.frontiersin.org/articles/10.3389/fcell.2020.602476/full

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