A non-functional neoepitope specific CD8+ T-cell response induced by tumor derived antigen exposure in vivo

A non-functional neoepitope specific CD8+ T-cell response induced by tumor derived antigen exposure in vivo

Cancer-associated mutations, mostly single nucleotide variations, can act as neoepitopes and prime targets for effective anti-cancer T-cell immunity. T cells recognizing cancer mutations are critical for the clinical activity of immune checkpoint blockade (ICB) and they are potent vaccine antigens....

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Bibliographic Details
Main Authors: Mathias Vormehr, Katharina Reinhard, Renata Blatnik, Kathrin Josef, Jan David Beck, Nadja Salomon, Martin Suchan, Abderraouf Selmi, Fulvia Vascotto, Johannes Zerweck, Holger Wenschuh, Mustafa Diken, Sebastian Kreiter, Özlem Türeci, Angelika B. Riemer, Ugur Sahin
Format: Article
Language:English
Published: Taylor & Francis Group 2019-03-01
Series:OncoImmunology
Subjects:
neoepitopes
cd8+ t cells
cancer immunotherapy
t cell priming
cd8+ t cell cytotoxicity
Online Access:http://dx.doi.org/10.1080/2162402X.2018.1553478

Internet

http://dx.doi.org/10.1080/2162402X.2018.1553478

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