Orphan Nuclear Receptor NR2F6 Suppresses T Follicular Helper Cell Accumulation through Regulation of IL-21

Orphan Nuclear Receptor NR2F6 Suppresses T Follicular Helper Cell Accumulation through Regulation of IL-21

Summary: CD4 T follicular helper (Tfh) cells are specialized in helping B cells during the germinal center (GC) reaction and ultimately promote long-term humoral immunity. Here we report that loss of the nuclear orphan receptor NR2F6 causes enhanced survival and accumulation of Tfh cells, GC B cells...

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Bibliographic Details
Main Authors: William J. Olson, Bojana Jakic, Verena Labi, Katia Schoeler, Michaela Kind, Victoria Klepsch, Gottfried Baier, Natascha Hermann-Kleiter
Format: Article
Language:English
Published: Elsevier 2019-09-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719310587

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http://www.sciencedirect.com/science/article/pii/S2211124719310587

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