Preponderance of CTLA4 Variation Associated With Autosomal Dominant Immune Dysregulation in the MYPPPY Motif

Preponderance of CTLA4 Variation Associated With Autosomal Dominant Immune Dysregulation in the MYPPPY Motif

One of the primary targets of immune checkpoint inhibition is the negative immune regulatory molecule CTLA-4. Immune-related adverse events are commonly observed following CTLA-4 inhibition in melanoma treatment, and a spectrum of these conditions are also observed in individuals with germline haplo...

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Bibliographic Details
Main Authors: Owen M. Siggs, Amanda Russell, Davinder Singh-Grewal, Melanie Wong, Pearl Chan, Maria E. Craig, Ted O'Loughlin, Michael Stormon, Christopher C. Goodnow
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Immunology
Subjects:
CTLA4
ipilimumab
CTLA-4
de novo variant
autoimmune hepatitis
abatacept
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01544/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01544/full

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