Specific miRNA and Gene Deregulation Characterize the Increased Angiogenic Remodeling of Thoracic Aneurysmatic Aortopathy in Marfan Syndrome

Specific miRNA and Gene Deregulation Characterize the Increased Angiogenic Remodeling of Thoracic Aneurysmatic Aortopathy in Marfan Syndrome

Marfan syndrome (MFS) is a connective tissue disease caused by mutations in the <i>FBN1</i> gene, leading to alterations in the extracellular matrix microfibril assembly and the early formation of thoracic aorta aneurysms (TAAs). Non-genetic TAAs share many clinico-pathological aspects w...

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Bibliographic Details
Main Authors: Federico D’Amico, Elena Doldo, Calogera Pisano, Maria Giovanna Scioli, Federica Centofanti, Giulia Proietti, Mattia Falconi, Federica Sangiuolo, Amedeo Ferlosio, Giovanni Ruvolo, Augusto Orlandi
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
Marfan syndrome
thoracic aortic aneurysm
fibrillin-1
aortic smooth muscle cells
Online Access:https://www.mdpi.com/1422-0067/21/18/6886

Internet

https://www.mdpi.com/1422-0067/21/18/6886

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