Analysis of Genetically Regulated Gene Expression Identifies a Prefrontal PTSD Gene, SNRNP35, Specific to Military Cohorts

Analysis of Genetically Regulated Gene Expression Identifies a Prefrontal PTSD Gene, SNRNP35, Specific to Military Cohorts

Summary: To reveal post-traumatic stress disorder (PTSD) genetic risk influences on tissue-specific gene expression, we use brain and non-brain transcriptomic imputation. We impute genetically regulated gene expression (GReX) in 29,539 PTSD cases and 166,145 controls from 70 ancestry-specific cohort...

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Bibliographic Details
Main Authors: Laura M. Huckins, Chris Chatzinakos, Michael S. Breen, Jakob Hartmann, Torsten Klengel, Ana C. da Silva Almeida, Amanda Dobbyn, Kiran Girdhar, Gabriel E. Hoffman, Claudia Klengel, Mark W. Logue, Adriana Lori, Adam X. Maihofer, Filomene G. Morrison, Hoang T. Nguyen, Yongjin Park, Douglas Ruderfer, Laura G. Sloofman, Sanne J.H. van Rooij, Dewleen G. Baker, Chia-Yen Chen, Nancy Cox, Laramie E. Duncan, Mark A. Geyer, Stephen J. Glatt, Hae Kyung Im, Victoria B. Risbrough, Jordan W. Smoller, Dan J. Stein, Rachel Yehuda, Israel Liberzon, Karestan C. Koenen, Tanja Jovanovic, Manolis Kellis, Mark W. Miller, Silviu-Alin Bacanu, Caroline M. Nievergelt, Joseph D. Buxbaum, Pamela Sklar, Kerry J. Ressler, Eli A. Stahl, Nikolaos P. Daskalakis
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Cell Reports
Subjects:
transcriptomic imputation
GWAS
PTSD
glucocorticoid
splicing
military
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720306938

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http://www.sciencedirect.com/science/article/pii/S2211124720306938

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