Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infection.

Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infection.

Legionella pneumophila (L. pneumophila), the causative agent of a severe form of pneumonia called Legionnaires' disease, replicates in human monocytes and macrophages. Most inbred mouse strains are restrictive to L. pneumophila infection except for the A/J, Nlrc4(-/-) (Ipaf(-/-)), and caspase-1...

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Bibliographic Details
Main Authors: Anwari Akhter, Mikhail A Gavrilin, Laura Frantz, Songcerae Washington, Cameron Ditty, Dominique Limoli, Colby Day, Anasuya Sarkar, Christie Newland, Jonathan Butchar, Clay B Marsh, Mark D Wewers, Susheela Tridandapani, Thirumala-Devi Kanneganti, Amal O Amer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-04-01
Series:PLoS Pathogens
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19343209/pdf/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19343209/pdf/?tool=EBI

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