UTX/KDM6A Loss Enhances the Malignant Phenotype of Multiple Myeloma and Sensitizes Cells to EZH2 inhibition

UTX/KDM6A Loss Enhances the Malignant Phenotype of Multiple Myeloma and Sensitizes Cells to EZH2 inhibition

Loss or inactivation of the histone H3K27 demethylase UTX occurs in several malignancies, including multiple myeloma (MM). Using an isogenic cell system, we found that loss of UTX leads to deactivation of gene expression ultimately promoting the proliferation, clonogenicity, adhesion, and tumorigeni...

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Bibliographic Details
Main Authors: Teresa Ezponda, Daphné Dupéré-Richer, Christine M. Will, Eliza C. Small, Nobish Varghese, Tej Patel, Behnam Nabet, Relja Popovic, Jon Oyer, Marinka Bulic, Yupeng Zheng, Xiaoxiao Huang, Mrinal Y. Shah, Sayantan Maji, Alberto Riva, Manuela Occhionorelli, Giovanni Tonon, Neil Kelleher, Jonathan Keats, Jonathan D. Licht
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Cell Reports
Subjects:
multiple myeloma
UTX
KDM6A
EZH2 inhibitors
IRF4
BCL6
PRC2
H3K27me3
epigenetic regulator
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717313839

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http://www.sciencedirect.com/science/article/pii/S2211124717313839

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