Resolving individuals contributing trace amounts of DNA to highly complex mixtures using high-density SNP genotyping microarrays.

Resolving individuals contributing trace amounts of DNA to highly complex mixtures using high-density SNP genotyping microarrays.

We use high-density single nucleotide polymorphism (SNP) genotyping microarrays to demonstrate the ability to accurately and robustly determine whether individuals are in a complex genomic DNA mixture. We first develop a theoretical framework for detecting an individual's presence within a mixt...

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Bibliographic Details
Main Authors: Nils Homer, Szabolcs Szelinger, Margot Redman, David Duggan, Waibhav Tembe, Jill Muehling, John V Pearson, Dietrich A Stephan, Stanley F Nelson, David W Craig
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-08-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2516199?pdf=render

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http://europepmc.org/articles/PMC2516199?pdf=render

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