Prenatal enzyme replacement therapy for Akp2−/− mice with lethal hypophosphatasia

Prenatal enzyme replacement therapy for Akp2−/− mice with lethal hypophosphatasia

Hypophosphatasia (HPP) is a congenital skeletal disease. Impairment of bone mineralization and seizures are due to a deficiency of tissue-nonspecific alkaline phosphatase (TNAP). Enzyme replacement therapy (ERT) is available as a highly successful treatment for pediatric-onset HPP. However, the pote...

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Bibliographic Details
Main Authors: Akihiro Hasegawa, Aki Nakamura-Takahashi, Masataka Kasahara, Nana Saso, Sonoko Narisawa, José Luis Millán, Osamu Samura, Haruhiko Sago, Aikou Okamoto, Akihiro Umezawa
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Regenerative Therapy
Subjects:
Alkaline phosphatase
Calcification
Hypophosphatasia
Enzyme replacement therapy
Prenatal diagnosis
Fetal therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S235232042100047X

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http://www.sciencedirect.com/science/article/pii/S235232042100047X

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