Combination Therapy in Fragile X Syndrome; Possibilities and Pitfalls Illustrated by Targeting the mGluR5 and GABA Pathway Simultaneously

Combination Therapy in Fragile X Syndrome; Possibilities and Pitfalls Illustrated by Targeting the mGluR5 and GABA Pathway Simultaneously

Fragile X syndrome (FXS) is the most common monogenetic cause of intellectual disability and autism. The disorder is characterized by altered synaptic plasticity in the brain. Synaptic plasticity is tightly regulated by a complex balance of different synaptic pathways. In FXS, various synaptic pathw...

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Bibliographic Details
Main Authors: Shimriet Zeidler, Helen de Boer, Renate K. Hukema, Rob Willemsen
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Fragile X syndrome
FMR1
GABA
bumetanide
mGluR5
automated tube test
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00368/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2017.00368/full

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