Chromosome Transplantation: A Possible Approach to Treat Human X-linked Disorders

Chromosome Transplantation: A Possible Approach to Treat Human X-linked Disorders

Many human genetic diseases are associated with gross mutations such as aneuploidies, deletions, duplications, or inversions. For these “structural” disorders, conventional gene therapy, based on viral vectors and/or on programmable nuclease-mediated homologous recombination, is still unsatisfactory...

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Bibliographic Details
Main Authors: Marianna Paulis, Lucia Susani, Alessandra Castelli, Teruhiko Suzuki, Takahiko Hara, Letizia Straniero, Stefano Duga, Dario Strina, Stefano Mantero, Elena Caldana, Lucia Sergi Sergi, Anna Villa, Paolo Vezzoni
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
genomic disorders
induced pluripotent stem cells
genetic therapy
chromosome transfer
chromosome transplantation
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050120300140

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http://www.sciencedirect.com/science/article/pii/S2329050120300140

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