Design and Characterization of a Human Monoclonal Antibody that Modulates Mutant Connexin 26 Hemichannels Implicated in Deafness and Skin Disorders

Design and Characterization of a Human Monoclonal Antibody that Modulates Mutant Connexin 26 Hemichannels Implicated in Deafness and Skin Disorders

Background: Mutations leading to changes in properties, regulation, or expression of connexin-made channels have been implicated in 28 distinct human hereditary diseases. Eight of these result from variants of connexin 26 (Cx26), a protein critically involved in cell-cell signaling in the inner ear...

Full description

Bibliographic Details
Main Authors: Liang Xu, Andrea Carrer, Francesco Zonta, Zhihu Qu, Peixiang Ma, Sheng Li, Federico Ceriani, Damiano Buratto, Giulia Crispino, Veronica Zorzi, Gaia Ziraldo, Francesca Bruno, Chiara Nardin, Chiara Peres, Flavia Mazzarda, Anna M. Salvatore, Marcello Raspa, Ferdinando Scavizzi, Youjun Chu, Sichun Xie, Xuemei Yang, Jun Liao, Xiao Liu, Wei Wang, Shanshan Wang, Guang Yang, Richard A. Lerner, Fabio Mammano
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Molecular Neuroscience
Subjects:
syndromic autosomal hereditary deafness
cochlea
keratinocytes
connexins
antibody library
antibody structure
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00298/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2017.00298/full

Similar Items