Allergen-Induced C5a/C5aR1 Axis Activation in Pulmonary CD11b<sup>+</sup> cDCs Promotes Pulmonary Tolerance through Downregulation of CD40

Allergen-Induced C5a/C5aR1 Axis Activation in Pulmonary CD11b<sup>+</sup> cDCs Promotes Pulmonary Tolerance through Downregulation of CD40

Activation of the C5/C5a/C5a receptor 1 (C5aR1) axis during allergen sensitization protects from maladaptive T cell activation. To explore the underlying regulatory mechanisms, we analyzed the impact of C5aR1 activation on pulmonary CD11b<sup>+</sup> conventional dendritic cells (cDCs) i...

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Bibliographic Details
Main Authors: Konstantina Antoniou, Fanny Ender, Tillman Vollbrandt, Yves Laumonnier, Franziska Rathmann, Chandrashekhar Pasare, Harinder Singh, Jörg Köhl
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Cells
Subjects:
allergic asthma
complement
conventional dendritic cell
c5a receptor
cd40
house-dust-mite
Online Access:https://www.mdpi.com/2073-4409/9/2/300

Internet

https://www.mdpi.com/2073-4409/9/2/300

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