A Novel Approach for the Identification of Pharmacogenetic Variants in <i>MT-RNR1</i> through Next-Generation Sequencing Off-Target Data

A Novel Approach for the Identification of Pharmacogenetic Variants in <i>MT-RNR1</i> through Next-Generation Sequencing Off-Target Data

Specific genetic variants in the mitochondrially encoded 12S ribosomal RNA gene (<i>MT-RNR1</i>) cause aminoglycoside-induced irreversible hearing loss. Mitochondrial DNA is usually not included in targeted sequencing experiments; however, off-target data may deliver this information. He...

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Bibliographic Details
Main Authors: Javier Lanillos, María Santos, Marta Carcajona, Juan María Roldan-Romero, Angel M. Martinez, Bruna Calsina, María Monteagudo, Luis Javier Leandro-García, Cristina Montero-Conde, Alberto Cascón, Paolo Maietta, Sara Alvarez, Mercedes Robledo, Cristina Rodriguez-Antona
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Journal of Clinical Medicine
Subjects:
pharmacogenomics
hearing loss
aminoglycoside antibiotics
off-target next-generation sequencing (NGS) data
<i>MT-RNR1</i>
bioinformatics
Online Access:https://www.mdpi.com/2077-0383/9/7/2082

Internet

https://www.mdpi.com/2077-0383/9/7/2082

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