Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia.

Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia.

We have developed an enhanced form of reduced representation bisulfite sequencing with extended genomic coverage, which resulted in greater capture of DNA methylation information of regions lying outside of traditional CpG islands. Applying this method to primary human bone marrow specimens from pat...

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Bibliographic Details
Main Authors: Altuna Akalin, Francine E Garrett-Bakelman, Matthias Kormaksson, Jennifer Busuttil, Lu Zhang, Irina Khrebtukova, Thomas A Milne, Yongsheng Huang, Debabrata Biswas, Jay L Hess, C David Allis, Robert G Roeder, Peter J M Valk, Bob Löwenberg, Ruud Delwel, Hugo F Fernandez, Elisabeth Paietta, Martin S Tallman, Gary P Schroth, Christopher E Mason, Ari Melnick, Maria E Figueroa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3380828?pdf=render

Internet

http://europepmc.org/articles/PMC3380828?pdf=render

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