Glucagon Potentiates Insulin Secretion Via β-Cell GCGR at Physiological Concentrations of Glucose

Glucagon Potentiates Insulin Secretion Via β-Cell GCGR at Physiological Concentrations of Glucose

Incretin-potentiated glucose-stimulated insulin secretion (GSIS) is critical to maintaining euglycemia, of which GLP-1 receptor (GLP-1R) on β-cells plays an indispensable role. Recently, α-cell-derived glucagon but not intestine-derived GLP-1 has been proposed as the critical hormone that potentiate...

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Bibliographic Details
Main Authors: Yulin Zhang, Chengsheng Han, Wenzhen Zhu, Guoyi Yang, Xiaohong Peng, Sohum Mehta, Jin Zhang, Liangyi Chen, Yanmei Liu
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cells
Subjects:
glucagon
GCGR
GLP-1R
α-cells
β-cells
glucose-stimulated insulin secretion
Online Access:https://www.mdpi.com/2073-4409/10/9/2495

Internet

https://www.mdpi.com/2073-4409/10/9/2495

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