Whole-genome genotyping and resequencing reveal the association of a deletion in the complex interferon alpha gene cluster with hypothyroidism in dogs

Whole-genome genotyping and resequencing reveal the association of a deletion in the complex interferon alpha gene cluster with hypothyroidism in dogs

Abstract Background Hypothyroidism is a common complex endocrinopathy that typically has an autoimmune etiology, and it affects both humans and dogs. Genetic and environmental factors are both known to play important roles in the disease development. In this study, we sought to identify the genetic...

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Bibliographic Details
Main Authors: Matteo Bianchi, Nima Rafati, Åsa Karlsson, Eva Murén, Carl-Johan Rubin, Katarina Sundberg, Göran Andersson, Olle Kämpe, Åke Hedhammar, Kerstin Lindblad-Toh, Gerli Rosengren Pielberg
Format: Article
Language:English
Published: BMC 2020-04-01
Series:BMC Genomics
Subjects:
Dog
Hypothyroidism
Genome-wide association study
Fine-mapping
Whole-genome sequencing
Long-read sequencing
Online Access:http://link.springer.com/article/10.1186/s12864-020-6700-3

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http://link.springer.com/article/10.1186/s12864-020-6700-3

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