Screening for genes that accelerate the epigenetic aging clock in humans reveals a role for the H3K36 methyltransferase NSD1

Screening for genes that accelerate the epigenetic aging clock in humans reveals a role for the H3K36 methyltransferase NSD1

Abstract Background Epigenetic clocks are mathematical models that predict the biological age of an individual using DNA methylation data and have emerged in the last few years as the most accurate biomarkers of the aging process. However, little is known about the molecular mechanisms that control...

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Bibliographic Details
Main Authors: Daniel E. Martin-Herranz, Erfan Aref-Eshghi, Marc Jan Bonder, Thomas M. Stubbs, Sanaa Choufani, Rosanna Weksberg, Oliver Stegle, Bekim Sadikovic, Wolf Reik, Janet M. Thornton
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Genome Biology
Subjects:
Aging
Epigenetics
DNA methylation
Epigenetic clock
Biological age
Developmental disorder
Online Access:http://link.springer.com/article/10.1186/s13059-019-1753-9

Internet

http://link.springer.com/article/10.1186/s13059-019-1753-9

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