Vitamin E (α- and γ-Tocopherol) Levels in the Community: Distribution, Clinical and Biochemical Correlates, and Association with Dietary Patterns
Little is known about the distribution and determinants of circulating vitamin E levels in a German population. In this cross-sectional study we assessed the distribution of both α- and γ-tocopherol levels, identified their clinical and biochemical correlates, and assessed their relationships with a...
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doaj-ce645a3b8c9e48beb9934aebc44de63a2020-11-24T21:08:42ZengMDPI AGNutrients2072-66432017-12-01101310.3390/nu10010003nu10010003Vitamin E (α- and γ-Tocopherol) Levels in the Community: Distribution, Clinical and Biochemical Correlates, and Association with Dietary PatternsSabina Waniek0Romina di Giuseppe1Tuba Esatbeyoglu2Sandra Plachta-Danielzik3Ilka Ratjen4Gunnar Jacobs5Ute Nöthlings6Manja Koch7Sabrina Schlesinger8Gerald Rimbach9Wolfgang Lieb10Institute of Epidemiology, University of Kiel, 24105 Kiel, GermanyInstitute of Epidemiology, University of Kiel, 24105 Kiel, GermanyInstitute of Human Nutrition and Food Science, University of Kiel, 24118 Kiel, GermanyInstitute of Epidemiology, University of Kiel, 24105 Kiel, GermanyInstitute of Epidemiology, University of Kiel, 24105 Kiel, GermanyInstitute of Epidemiology, University of Kiel, 24105 Kiel, GermanyDepartment of Nutrition and Food Sciences, University of Bonn, 53113 Bonn, GermanyInstitute of Epidemiology, University of Kiel, 24105 Kiel, GermanyInstitute of Epidemiology, University of Kiel, 24105 Kiel, GermanyInstitute of Human Nutrition and Food Science, University of Kiel, 24118 Kiel, GermanyInstitute of Epidemiology, University of Kiel, 24105 Kiel, GermanyLittle is known about the distribution and determinants of circulating vitamin E levels in a German population. In this cross-sectional study we assessed the distribution of both α- and γ-tocopherol levels, identified their clinical and biochemical correlates, and assessed their relationships with a priori and a posteriori derived dietary patterns. Plasma α- and γ-tocopherol concentrations were measured using high performance liquid chromatography (HPLC) with fluorescence detection in 641 individuals (mean-age: 61 years; 40.6% women). Correlates of both markers were determined using linear regression with backward selection. Using a validated food-frequency questionnaire (FFQ), an a priori defined vitamin E-rich dietary pattern was constructed, and three a posteriori derived dietary patterns were identified by principal component analysis. Each pattern was related to α- and γ-tocopherol levels using linear regression. Median concentrations of α- and γ-tocopherol were 31.54 μmol/L and 1.35 µmol/L, respectively. 57.6% of participants had α-tocopherol levels >30 µmol/L. Triglycerides, high density lipoprotein (HDL)- and low density lipoprotein (LDL)-cholesterol, and vitamin E supplementation were identified as correlates of vitamin E levels. After excluding supplement users, a dietary pattern rich in meat, bread, fats, potatoes, and sugar/confectionery was inversely related to α-tocopherol levels (β, −0.032, SE = 0.016; p = 0.047). Prospective studies are warranted to evaluate the actual impact of the reported findings in terms of nutrition and health outcomes.https://www.mdpi.com/2072-6643/10/1/3vitamin Eα-tocopherolγ-tocopheroldietary patterns |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sabina Waniek Romina di Giuseppe Tuba Esatbeyoglu Sandra Plachta-Danielzik Ilka Ratjen Gunnar Jacobs Ute Nöthlings Manja Koch Sabrina Schlesinger Gerald Rimbach Wolfgang Lieb |
spellingShingle |
Sabina Waniek Romina di Giuseppe Tuba Esatbeyoglu Sandra Plachta-Danielzik Ilka Ratjen Gunnar Jacobs Ute Nöthlings Manja Koch Sabrina Schlesinger Gerald Rimbach Wolfgang Lieb Vitamin E (α- and γ-Tocopherol) Levels in the Community: Distribution, Clinical and Biochemical Correlates, and Association with Dietary Patterns Nutrients vitamin E α-tocopherol γ-tocopherol dietary patterns |
author_facet |
Sabina Waniek Romina di Giuseppe Tuba Esatbeyoglu Sandra Plachta-Danielzik Ilka Ratjen Gunnar Jacobs Ute Nöthlings Manja Koch Sabrina Schlesinger Gerald Rimbach Wolfgang Lieb |
author_sort |
Sabina Waniek |
title |
Vitamin E (α- and γ-Tocopherol) Levels in the Community: Distribution, Clinical and Biochemical Correlates, and Association with Dietary Patterns |
title_short |
Vitamin E (α- and γ-Tocopherol) Levels in the Community: Distribution, Clinical and Biochemical Correlates, and Association with Dietary Patterns |
title_full |
Vitamin E (α- and γ-Tocopherol) Levels in the Community: Distribution, Clinical and Biochemical Correlates, and Association with Dietary Patterns |
title_fullStr |
Vitamin E (α- and γ-Tocopherol) Levels in the Community: Distribution, Clinical and Biochemical Correlates, and Association with Dietary Patterns |
title_full_unstemmed |
Vitamin E (α- and γ-Tocopherol) Levels in the Community: Distribution, Clinical and Biochemical Correlates, and Association with Dietary Patterns |
title_sort |
vitamin e (α- and γ-tocopherol) levels in the community: distribution, clinical and biochemical correlates, and association with dietary patterns |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2017-12-01 |
description |
Little is known about the distribution and determinants of circulating vitamin E levels in a German population. In this cross-sectional study we assessed the distribution of both α- and γ-tocopherol levels, identified their clinical and biochemical correlates, and assessed their relationships with a priori and a posteriori derived dietary patterns. Plasma α- and γ-tocopherol concentrations were measured using high performance liquid chromatography (HPLC) with fluorescence detection in 641 individuals (mean-age: 61 years; 40.6% women). Correlates of both markers were determined using linear regression with backward selection. Using a validated food-frequency questionnaire (FFQ), an a priori defined vitamin E-rich dietary pattern was constructed, and three a posteriori derived dietary patterns were identified by principal component analysis. Each pattern was related to α- and γ-tocopherol levels using linear regression. Median concentrations of α- and γ-tocopherol were 31.54 μmol/L and 1.35 µmol/L, respectively. 57.6% of participants had α-tocopherol levels >30 µmol/L. Triglycerides, high density lipoprotein (HDL)- and low density lipoprotein (LDL)-cholesterol, and vitamin E supplementation were identified as correlates of vitamin E levels. After excluding supplement users, a dietary pattern rich in meat, bread, fats, potatoes, and sugar/confectionery was inversely related to α-tocopherol levels (β, −0.032, SE = 0.016; p = 0.047). Prospective studies are warranted to evaluate the actual impact of the reported findings in terms of nutrition and health outcomes. |
topic |
vitamin E α-tocopherol γ-tocopherol dietary patterns |
url |
https://www.mdpi.com/2072-6643/10/1/3 |
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