QSAR Model of Indeno[1,2-<i>b</i>]indole Derivatives and Identification of <i>N</i>-isopentyl-2-methyl-4,9-dioxo-4,9-Dihydronaphtho[2,3-<i>b</i>]furan-3-carboxamide as a Potent CK2 Inhibitor

QSAR Model of Indeno[1,2-<i>b</i>]indole Derivatives and Identification of <i>N</i>-isopentyl-2-methyl-4,9-dioxo-4,9-Dihydronaphtho[2,3-<i>b</i>]furan-3-carboxamide as a Potent CK2 Inhibitor

Casein kinase II (CK2) is an intensively studied enzyme, involved in different diseases, cancer in particular. Different scaffolds were used to develop inhibitors of this enzyme. Here, we report on the synthesis and biological evaluation of twenty phenolic, ketonic, and <i>para</i>-quino...

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Bibliographic Details
Main Authors: Samer Haidar, Christelle Marminon, Dagmar Aichele, Abdelhamid Nacereddine, Wael Zeinyeh, Abdeslem Bouzina, Malika Berredjem, Laurent Ettouati, Zouhair Bouaziz, Marc Le Borgne, Joachim Jose
Format: Article
Language:English
Published: MDPI AG 2019-12-01
Series:Molecules
Subjects:
qsar
cancer
ck2
indeno[1,2-<i>b</i>]indole
naphtho[2,3-<i>b</i>]furan-4,9-dione
Online Access:https://www.mdpi.com/1420-3049/25/1/97

Internet

https://www.mdpi.com/1420-3049/25/1/97

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