QSAR Model of Indeno[1,2-<i>b</i>]indole Derivatives and Identification of <i>N</i>-isopentyl-2-methyl-4,9-dioxo-4,9-Dihydronaphtho[2,3-<i>b</i>]furan-3-carboxamide as a Potent CK2 Inhibitor
Casein kinase II (CK2) is an intensively studied enzyme, involved in different diseases, cancer in particular. Different scaffolds were used to develop inhibitors of this enzyme. Here, we report on the synthesis and biological evaluation of twenty phenolic, ketonic, and <i>para</i>-quino...
Main Authors: | Samer Haidar, Christelle Marminon, Dagmar Aichele, Abdelhamid Nacereddine, Wael Zeinyeh, Abdeslem Bouzina, Malika Berredjem, Laurent Ettouati, Zouhair Bouaziz, Marc Le Borgne, Joachim Jose |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-12-01
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Series: | Molecules |
Subjects: | |
Online Access: | https://www.mdpi.com/1420-3049/25/1/97 |
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