Inhibition of Thrombopoietin/Mpl Signaling in Adult Hematopoiesis Identifies New Candidates for Hematopoietic Stem Cell Maintenance.

Inhibition of Thrombopoietin/Mpl Signaling in Adult Hematopoiesis Identifies New Candidates for Hematopoietic Stem Cell Maintenance.

Thrombopoietin (Thpo) signals via its receptor Mpl and regulates megakaryopoiesis, hematopoietic stem cell (HSC) maintenance and post-transplant expansion. Mpl expression is tightly controlled and deregulation of Thpo/Mpl-signaling is linked to hematological disorders. Here, we constructed an intrac...

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Bibliographic Details
Main Authors: Saskia Kohlscheen, Sabine Wintterle, Adrian Schwarzer, Christel Kamp, Martijn H Brugman, Daniel C Breuer, Guntram Büsche, Christopher Baum, Ute Modlich
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4493002?pdf=render

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http://europepmc.org/articles/PMC4493002?pdf=render

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