A genome-wide association study identifies rs2000999 as a strong genetic determinant of circulating haptoglobin levels.

A genome-wide association study identifies rs2000999 as a strong genetic determinant of circulating haptoglobin levels.

Haptoglobin is an acute phase inflammatory marker. Its main function is to bind hemoglobin released from erythrocytes to aid its elimination, and thereby haptoglobin prevents the generation of reactive oxygen species in the blood. Haptoglobin levels have been repeatedly associated with a variety of...

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Main Authors: Philippe Froguel, Ndeye Coumba Ndiaye, Amélie Bonnefond, Nabila Bouatia-Naji, Aurélie Dechaume, Gérard Siest, Bernard Herbeth, Mario Falchi, Leonardo Bottolo, Rosa-Maria Guéant-Rodriguez, Cécile Lecoeur, Michel R Langlois, Yann Labrune, Aimo Ruokonen, Said El Shamieh, Maria G Stathopoulou, Anita Morandi, Claudio Maffeis, David Meyre, Joris R Delanghe, Peter Jacobson, Lars Sjöström, Lena M S Carlsson, Andrew Walley, Paul Elliott, Marjo-Riita Jarvelin, George V Dedoussis, Sophie Visvikis-Siest
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3293812?pdf=render

Internet

http://europepmc.org/articles/PMC3293812?pdf=render

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