Compromised Barrier Function in Human Induced Pluripotent Stem-Cell-Derived Retinal Pigment Epithelial Cells from Type 2 Diabetic Patients

Compromised Barrier Function in Human Induced Pluripotent Stem-Cell-Derived Retinal Pigment Epithelial Cells from Type 2 Diabetic Patients

In diabetic patients, high blood glucose induces alterations in retinal function and can lead to visual impairment due to diabetic retinopathy. In immortalized retinal pigment epithelial (RPE) cultures, high glucose concentrations are shown to lead to impairment in epithelial barrier properties. For...

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Bibliographic Details
Main Authors: Mostafa Kiamehr, Alexa Klettner, Elisabeth Richert, Ali Koskela, Arto Koistinen, Heli Skottman, Kai Kaarniranta, Katriina Aalto-Setälä, Kati Juuti-Uusitalo
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:International Journal of Molecular Sciences
Subjects:
retinal pigment epithelial cells
type 2 diabetes
diabetic retinopathy (DR)
induced pluripotent stem cells (hiPSC)
barrier function
autophagy
matrix metalloproteinase
Online Access:https://www.mdpi.com/1422-0067/20/15/3773

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https://www.mdpi.com/1422-0067/20/15/3773

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