Targeting the Non-catalytic RVxF Site of Protein Phosphatase-1 With Small Molecules for Ebola Virus Inhibition

Targeting the Non-catalytic RVxF Site of Protein Phosphatase-1 With Small Molecules for Ebola Virus Inhibition

Ebola virus (EBOV) is a non-segmented negative-sense RNA virus that causes a severe human disease. The ongoing EBOV outbreak in the Eastern part of Democratic Republic of the Congo has resulted to date in over 2500 confirmed cases including over 1500 deaths. Difficulties with vaccine administration...

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Bibliographic Details
Main Authors: Xionghao Lin, Tatiana Ammosova, Meng S. Choy, Colette A. Pietzsch, Andrey Ivanov, Asrar Ahmad, Yasemin Saygideğer, Namita Kumari, Dmytro Kovalskyy, Aykut Üren, Wolfgang Peti, Alexander Bukreyev, Sergei Nekhai
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Microbiology
Subjects:
Ebola virus
protein phosphatase-1
small molecule EBOV inhibitor
protein painting
surface plasmon resonance
split NanoBiT
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.02145/full

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https://www.frontiersin.org/article/10.3389/fmicb.2019.02145/full

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