RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs.

RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs.

Triple negative breast cancer (TNBC) includes basal-like and claudin-low subtypes for which only chemotherapy and radiation therapy are currently available. The retinoblastoma (RB1) tumor suppressor is frequently lost in human TNBC. Knockdown of RB1 in luminal BC cells was shown to affect response t...

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Bibliographic Details
Main Authors: Tyler J W Robinson, Jeff C Liu, Frederick Vizeacoumar, Thomas Sun, Neil Maclean, Sean E Egan, Aaron D Schimmer, Alessandro Datti, Eldad Zacksenhaus
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3827056?pdf=render

Internet

http://europepmc.org/articles/PMC3827056?pdf=render

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