Altered bone development and an increase in FGF-23 expression in Enpp1(-/-) mice.

Altered bone development and an increase in FGF-23 expression in Enpp1(-/-) mice.

Nucleotide pyrophosphatase phosphodiesterase 1 (NPP1) is required for the conversion of extracellular ATP into inorganic pyrophosphate (PP(i)), a recognised inhibitor of hydroxyapatite (HA) crystal formation. A detailed phenotypic assessment of a mouse model lacking NPP1 (Enpp1(-/-)) was completed t...

Full description

Bibliographic Details
Main Authors: Neil Charles Wallace Mackenzie, Dongxing Zhu, Elspeth M Milne, Rob van 't Hof, Aline Martin, Leigh Darryl Quarles, José Luis Millán, Colin Farquharson, Vicky Elisabeth MacRae
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3281127?pdf=render

Internet

http://europepmc.org/articles/PMC3281127?pdf=render

Similar Items